This article describes the discovery of nuclear DNA‐like RNA (dRNA or hnRNA) and ribonucleoprotein particles in eukaryotes. Native hnRNA particles were isolated by sucrose gradient sedimentation and their structural organisation – nucleic acid (i.e. RNA) wrapped in a regular way on the surface of a series of globular protein particles – was determined. This led to the formulation of the informofer cycle hypothesis for the synthesis of hnRNA as a giant precursor molecule, its transport in informosomes within the nucleus, and (...) subsequent splicing before export from the nucleus as free mRNA. (shrink)

This article discusses Aristotle’s description of the virtuous person as inclined to superiority and to contempt. The issue is about superiority in the act, which is expressed in leading the origin of the act upwards to oneself, that is, about the superiority of the moral subject’s being. Contempt is not an estimation but something like a gesture removing any obstacle to being oneself. Aristotle creates a unified image to personify the idea of the moral subject and to answer the question (...) of being human. (shrink)

The author analyses the change in the Tamil Śaiva bhakti concept of corporeality showing that understanding the body of a bhakta as the main obstacle to connecting with the body of Śiva based on the attitude of rejecting one's corporeality has much in common with Buddhist and Jain ideas about the body. Therefore, the main task of the bhakta was to liberate from his body, its elimination or transformation (remelting the physical body as an impure body, as an obstacle body (...) on the way to union with God). They solved this task in various ways, including various practices of ecstatic behaviour and self-harm. The concept of kaya siddhi put forward by Tirumūlar is the idea of a perfect body, potentially immortal and homologous to the body of Śiva. He also formulated and developed sophisticated techniques for using the physical body of a sādhaka as the primary tool for achieving liberation based on yoga techniques and working with the mind of an adept. The result achieved was presented in the description of Tirumūlar's own mystical experience. As a result, he achieved the state of the super material body of yoga-deha, the ideal of which is the manifest body of Śiva as Naṭarāja. The new iconography of Naṭarāja formed in the visionary insights of bhaktas, who described their darśans in their hymns. Then it became the basis for forming a new iconology of Naṭarāja and the cult of images of the bhaktas themselves embodied in the intensive temple construction of the Chola Empire. In combination with new ritual practices, the Tamil philosophy of Śaivism had formed as a tripartite religious and philosophical canon of Śaiva Siddhānta. This canon included the poetic canon of Śaiva bhakti (Paṉṉiru Tirumuṟai), the agamic temple ritual, and 14 philosophical treatises of Śaiva Siddhānta (Meikaṇṭar Shastras). (shrink)

The present study examines cross-cultural differences in people’s concept of lying with regard to the question of whether lying requires an agent to _say_ something they believe to be false. While prominent philosophical views maintain that lying entails that a person explicitly expresses a believed-false claim, recent research suggests that people’s concept of lying might also include certain kinds of deception that are communicated more indirectly. An important drawback of previous empirical work on this topic is that only few studies (...) have investigated people’s concept of lying in non-Western samples. In the present study, we compare people’s intuitions about lying with indirect deceptions (i.e., presuppositions, conversational implicatures, and non-verbal actions) in a sample of _N_ = 255 participants from Russia and _N_ = 300 participants from the United Kingdom. Our findings show a strong degree of similarity between lie ratings of participants from Russia and the United Kingdom, with both samples holding it possible for agents to lie with deceptive statements and actions that do not involve the agent _saying_ something they believe to be false. (shrink)

Aims: Attentional bias, alcohol craving, and anxiety have important implications in the development and maintenance of alcohol use disorder. The current study aims to test the effectiveness of a Virtual Reality Cue-Exposure Therapy to reduce levels of alcohol craving and anxiety and prompt changes in AB toward alcohol content.Method: A 49-year-old male participated in this study, diagnosed with severe AUD, who also used tobacco and illicit substances on an occasional basis and who made several failed attempts to cease substance misuse. (...) The protocol consisted of six VR-CET booster sessions and two assessment sessions over the course of 5 weeks. The VR-CET program consisted of booster therapy sessions based on virtual reality exposure to preferred alcohol-related cues and contexts. The initial and final assessment sessions were focused on exploring AB, alcohol craving, and anxiety using paper-and-pencil instruments and the eye-tracking and VR technologies at different time points.Results: Pre and post assessment sessions indicated falls on the scores of all instruments assessing alcohol craving, anxiety, and AB.Conclusions: This case report, part of a larger project, demonstrates the effectiveness of the VR-CET booster sessions in AUD. In the post-treatment measurements, a variety of instruments showed a change in the AB pattern and an improvement in craving and anxiety responses. As a result of the systematic desensitization, virtual exposure gradually reduced the responses to significant alcohol-related cues and contexts. The implications for AB, anxiety and craving are discussed. (shrink)

BackgroundCurrent preimplantation genetic testing (PGT) technologies enable embryo genotyping across the whole genome. This has led to the development of polygenic risk scoring of human embryos (PGT-P). Recent implementation of PGT-P, including screening for intelligence, has been extensively covered by media reports, raising major controversy. Considering the increasing demand for assisted reproduction, we evaluated how information about PGT-P is communicated in press media and explored the diversity of ethical themes present in the public debate.MethodsLexisNexis Academic database and Google News were (...) searched to identify articles about polygenic embryo screening. This led to 535 news articles. 59 original articles met the inclusion criteria. Inductive content analysis was used to analyse these articles.Results8.8% of articles gave embryo polygenic scoring a positive portrayal, while 36.8% expressed a negative attitude. 54.4% were neutral, mostly highlighting limited practical value of the technology in in vitro fertilization settings. We identified five main ethical themes that are also present in academic literature and the broader debate on reproductive technologies: a slippery slope towards designer babies, well-being of the child and parents, impact on society, deliberate choice and societal readiness.ConclusionsImplementation of embryo polygenic profiling engenders a need for specific recommendations. Current media analysis discloses important ethical themes to consider when creating future guidelines for PGT-P. (shrink)

In addition to probabilities of monetary gains and losses, personality traits, socio-economic factors, and specific contexts such as emotions and framing influence financial risk taking. Here, we investigated the effects of joyful, neutral, and sad mood states on participants’ risk-taking behaviour in a simple task with safe and risky options. We also analysed the effect of framing on risk taking. In different trials, a safe option was framed in terms of either financial gains or losses. Moreover, we investigated the effects (...) of emotional contagion and sensation-seeking personality traits on risk taking in this task. We did not observe a significant effect of induced moods on risk taking. Sad mood resulted in a slight non-significant trend of risk aversion compared to a neutral mood. Our results partially replicate previous findings regarding the presence of the framing effect. As a novel finding, we observed that participants with a low emotional contagion score demonstrated increased risk aversion during a sad mood and a similar trend at the edge of significance was present in high sensation seekers. Overall, our results highlight the importance of taking into account personality traits of experimental participants in financial risk-taking studies. (shrink)

At the bedside, nurses are expected to be precise when they read indications on screens and on the bodies of patients and decide on the meaning of words framed by the context of acute care. In academia, although there is no incident report to fill when we misread or misrepresent complex philosophical ideas, the consequences of inaccurate reading include misplaced epistemological claims and poor scholarship. A long and broad convention of nursing phenomenological research, in its various forms, claims a philosophical (...) grounding in the ideas of Husserl, Heidegger, and other thinkers. But for nearly two decades, nurse phenomenologists' knowledge claims have been challenged by well‐informed criticisms, most notably by John Paley. At the heart of criticism lies an observation that Continental phenomenological thought is misrepresented in many nursing sources and that nursing phenomenology, both descriptive and interpretive, cannot appeal to the authority of either Husserl or Heidegger. Taking these criticisms seriously, I am asking, Is phenomenology after Paley possible? If misreading seems to be an issue, how can – or should – we read rigorously? My thinking through these questions is influenced by the ideas of Jacques Derrida. Under a condition of a play of language, of Derridian différance, when meaning is never self‐identical and never fully arrives, I suggest that one has to negotiate meanings through reading for differences. I develop this idea in relation to the methodological conventions of phenomenological nursing research and argue for a careful rereading of the whole field of phenomenological nursing research. Such rereading presupposes and necessitates interdisciplinary engagement between nursing and the humanities and interpretive social sciences. Greater familiarity with research practices of those disciplines that stress theoretical and writing rigour might make visible the limits of nursing research approaches and their quality criteria. An understanding of philosophical and theoretical works – a condition of quality scholarship – depends on our reading of both originary texts and contemporary literature from the humanities and the social sciences. This understanding, far from obliging researchers to always trace (often erroneously) their work to its philosophical roots, opens other, often more sound, methodological possibilities. (shrink)

Le Glossaire du latin philosophique est un fichier d'environ 230.000 à 260.000 fiches consacré au vocabulaire philosophique du moyen âge. Une équipe du CNRS, au départ sous la direction de Pierre Michaud-Quantin, y a travaillé durant de nombreuses années. Récemment, il a été transporté de la Sorbonne à l'Institut de Recherche et d'Histoire des Textes, où il est désormais consultable à la Section latine. À l'occasion de l'arrivée du Glossaire du latin philosophique à l'Institut de Recherche et d'Histoire des Textes (...) et pour marquer un nouveau départ, une journée d'étude consacrée à ce fi chier a eu lieu à l'IRHT, le jeudi 15 mai 2008, sous le titre "Les innovations du vocabulaire latin à la fin du moyen âge:autour du Glossaire du latin philosophique." -- P. [4} of cover. (shrink)

In this article dedicated to Lev P. Karsavin’s creative path, I focus mainly on the evolution of the thinker’s religious–philosophical ideas. I consider the reasons that prompted the professional historian to choose the path of a free philosopher, defending an argument about the interrelation of Karsavin’s historiosophical ideas and the key provisions of his metaphysics. The article assesses the philosopher’s legacy in the context of the problem of Russian religious metaphysics as an independent and significant intellectual tradition that has shaped (...) Russian cultural history among other spiritual–intellectual practices. In denoting the perspective of Karsavin’s activity, the author suggests key tasks in studying the philosopher’s work. These include, on the one hand, revising the corpus of Karsavin studies, and on the other hand, polemicizing with already existing interpretations of his work in Karsavin studies both in Russia and abroad. This strategy allows the author to conduct reinterpretations of Karsavin’s personological, onto-epistemological, and cultural–historical understandings that constitute the theoretical core of his religious metaphysics. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

In his book, Simon Franklin investigates various writings attested in Rus. This, however, does not automatically mean “Russian writings.” As the author himself states in the first sentence of his work, “This book is about the origins and early uses of writings in a particular society (Rus), but it may also serve as a case-study for those with a broader interest either in medieval uses of writing or—still more broadly—in the cultural history of information technology” (p. 1).

The steady growth of the number of DNA tests offered results in the discussion on the ethical aspects of these tests becoming increasingly lively and multifaceted. This text provides an overview of selected issues concerning the characteristics, protection and quality of the information acquired as a result of carrying out DNA tests. I discuss the salient points in the debates on the possibility to justify the so-called genetic exceptionalism, and the ways of specifying the scope of the principle of confidentiality (...) that protects the privacy of the information given by the subject. The final part of the article features the discussion on the importance of the possibility to use the information, acquired from these tests, in practice – for making decisions about the introduction of new kinds of tests for the clinical application. (shrink)

This article examines the concept of the perfect, a key idea in Lev P. Karsavin’s metaphysics that largely determines his understanding of personhood and its ontological status. The associated concept of the perfect person develops throughout the entire philosophical period of the thinker’s work, from his Philosophy of History to his treatise “On Perfection,” written in the last year of his life in the Abez’ camps. In this article, I argue that the concept of perfection is the main structural element (...) in Karsavin’s religious–philosophical system, making it ontologically full and complete. I believe the Christian idea of the perfection of man in God, philosophical variations of which Karsavin finds in Nicholas of Cusa’s system of total unity and Vladimir Solovyov’s idea of Godmanhood, is both the initial intellectual intuition and the ontological premise of the thinker’s metaphysical constructions. His religious–philosophical work has a continuity with Russian culture’s spiritual tradition, where patristic thought of man considers the ideal to be the spiritual transcendence of the person in his striving toward the Perfect God. This evangelic idea turns out to be the central binding element both of Karsavin’s Christian personology and of his metaphysics of history, which is resolved in a metaphysical vein. (shrink)

In today's conditions, the heavy resistance of Ukrainians to Russian aggression, which is carried out, with the exception of the military, by way of information and economic methods, and now also through a non-gossip "hybrid" confrontation, it is very important to properly evaluate and play an appropriate role in this religious and religious factor. "Russian World" is no less effective weapon of the Moscow Church in the war with Ukraine than the military aid of the Russian state to the separatists.. (...) Religious communities have their potential in educating citizens - patriots of their homeland, or else. Different aspects of the problem of the role of religious-church factors in patriotic education of Ukrainians have long been in the zone of justified attention of domestic secular scholars and representatives of the Churches, among them: A. Kolodny, L. Filippovich, V. Shevchenko, P. Pavlenko, O. Sagan, C. Zdioruk, M. Cherenkov, O. Tuyeshin and others. Particular attention of the RCC and Protestant Churches in this regard was given by P. L. Yarotsky. (shrink)

The article deals with the philosophical problem field of modern neuroethics. The general idea of the state of modern neuroethics is given and it is shown that research in this area encompasses both fundamental problems that classically belonged to the field of philosophy research (for example, such as the problem of psychophysical dualism, the physical bases of consciousness, freedom of will and its interrelation with brain activity) and problems with applied orientation, explicating the ethical-social and legal dimension of innovation development (...) in the field of neuroscience and actualizing the analysis of their social risks. It is shown that the development of neuro-ethics in the modern world became possible thanks to a special way of functioning of modern science, which was called the technology of science and to the development of the phenomenon of technological development ethification, which in practical terms was expressed in the study of the problem of the correspondence of the results of innovative scientific and technical projects to the interests of various social groups, their expectations and values, and also helped to determine the status of new technologies in relation to social reality. The article gives an idea of the existing normative field necessary for the development of neuro-ethics. On the basis of using the resource of discourse analysis of R. Harre, who singled out personal grammar (P-grammar), organism grammar (O-grammars) and molecular grammar (M-grammar), a philosophical analysis of such a problem of modern neuroethics as brain death was carried out. Also was given a structural description of new biotechnogenic identities of human being. The conclusion is drawn that the concept of brain death is an example of the conventional nature of scientific truth, the formation of which is influenced by various socio-cultural and economic factors. In the context of the development of neuroscience and the emergence of new methods of brain regeneration, it can be rethought. (shrink)

Capricci are nonsense drawings that delineate an elusive but inevitable sense behind or, better, within the palpable nonsense of the elementary proposition of a drawing; they are capers on a tightrope stretched between the poles of pathos and the ridiculous. We shall succeed in not falling only if we step forward boldly and know not only what we are doing but also what we are up against in the making of a picture as well as in living in the world. (...) For the world, in its yawning impudence of death and the dance of blind eagerness, ambition, and noisy speechlessness, makes us look to art not, or not necessarily, to escape from the world but rather to learn how to take its measure. . . . There is a painting ["St. Vincent Ferrer Preaching"] joined to the Passion cycle in S. Polo which demonstrates as well as any paradox ever will how Giandomenico joined piety and irony in his religious art without curtailing the glory of either. He arrives, as it were, at a God-fearing irony. We see St. Vincent Ferrer preaching. He speaks so eloquently, so convincingly in praise of the divine truth, that light shines forth from him and angel's wings grow on his shoulders. Fascinated by the miracle but even more so by the saint's words, his audience sits spellbound at his feet; in the foreground, however, sits a youth, a fop perhaps, gorgeously dressed, with a singular smile on his face, his hand musingly poised to his cheek, who looks at us quizzically. He is the link between us and the miracle. "Can you believe it?" says the smile, and perhaps "I did not—and yes—how can you now not believe it, you need but look - as I did - for there it is!" It is, I think, the face of one who knows about the truth of the absurd and its inner logic. Credo quia absurdum: if it were not so, we could prove the existence of God by feeding data into a computer, and there would be many believers, whose faith, in turn, deserved but little credit. Needless to say, perhaps, the face that so speaks to us in laughter joined to wonder is a self-portrait.1 · 1. In S. Polo the painting of St. Vincent Ferrer Preaching hangs opposite a matching picture of The Finding of the True Cross. There is a beautiful young woman on the right who looks at us beseechingly and with her right hand points at the cross. Giovanni Domenico Tiepolo who looks out of St. Vincent Ferrer Preaching cannot help but see this lady and be affected by her earnest gesture. For a reproduction of the painting, see Maruz, G. D. Tiepolo, plate 22. Philipp P. Fehl is a professor in the department of art and design at the University of Illinois at Urbana-Champaign. He has edited Franciscus Junius: The Literature of Classical Art. His previous contribution to Critical Inquiry, "Turner's Classicism and the Problem of Periodization in the History of Art," appeared in the Autumn 1976 issue; the present essay was delivered in an earlier version at Stanford University in 1976 and is included in his collection of essays, Art and Mortality. His capricci, Birds with Titles, were exhibited in a one-man show at Kenyon College. (shrink)

En este artículo se trata sobre la controvertida cuestión del origen de la amidá, principal oración del servicio religioso judío, en el contexto de creación de la liturgia rabínica tras la destrucción del Templo de Jerusalén en el año 70 d. C. Para ello se analiza primero su estructura formal y literaria, ofreciendo a continuación un análisis crítico sobre su origen que se hace eco del debate académico acerca de la cuestión. En apéndice se ofrece una traducción anotada de esta (...) oración rabínica del s. I d. C. (shrink)

Paru en URSS au moment de la perestroïka (1989), sous le titre Cela pèse jusqu'à aujourd'hui, ce recueil prend place dans une collection de qualité, qui a publié notamment des textes de V.Chalamov, connu pour ses Récits de Kolyma. Il regroupe quatorze témoignages de femmes qui ont été détenues dans les prisons et les camps soviétiques entre 1922 et 1965. Certes, ce n'est pas la première fois que le public français peut lire des souvenirs d'ex-prisonnières, mais ce volume vaut d'abord (...) p... (shrink)

Ferrer, Vicent (2021)De suppositionibusEdició crítica del text llatí, traducció catalana, introducció a cura de Josep Batalla i Elena de la Cruz Vergari, traducció anglesa de Robert D. HughesSanta Coloma de Queralt: Obrador Edèndum, 793 p.ISBN 978-84-120007-4-0.

Tienen razón Francisco Lara y Olga Campos en afirmar en la introducción de su libro que “un mérito importante de este libro es que, de manera muy divulgativa, pretende dar respuestas filosóficas al debate sobre nuestra relación con los animales al aplicar ideas bási- cas a cuestiones prácticas como si debemos ser o no vegetarianos, si hay que experimentar con animales o hasta qué punto son justifica- bles las corridas de toros” (p. 15). Y efectivamente, de una manera muy (...) clara, el libro no sólo pretende, sino que en efecto da respuestas a cuestiones centrales sobre nuestra relación con los animales, en particular a la cuestión acerca de cuál es su estatus o su valor moral y, por ende, sobre si tenemos obligaciones morales hacia ellos. Su tesis es que los animales sí tienen un estatus moral independiente de los intereses humanos, que tienen derechos y que es nuestra obligación moral respetarlos. Parte de ese respeto consiste en no tratarlos como meros instrumentos o recursos al servicio de los inte- reses de los humanos. (shrink)

LA ÉTICA DE EDMUND HUSSERL trata de recoger la doctrina ética de Edmund Husserl (1859–1938), con la idea de dar a conocer el contenido moral que encierra la rica obra husserliana. Además, constituye una buena introducción a quienes se aproximan a la filosofía del fundador de la fenomenología, y un buen servicio incluso para quienes ya conocen su pensamiento solamente en relación con la teoría del conocimiento o con la lógica. Concretamente, la ética de Husserl —en un cuidado y ajustado (...) equilibrio entre el papel de la razón, el de la voluntad y el del sentimiento— ofrece la posibilidad de rescatar la afectividad del sentimentalismo ciego e instintivo sin caer en el extremo contrario del racionalismo inhumano; enseña cómo tomar libre y realmente nuestra vida en nuestras propias manos y dirigirnos a un ideal personal; muestra cómo comportarnos con nuestros semejantes reconociéndolos en su verdadera dignidad, y cómo podemos ayudarnos los unos a los otros. Y para todo ello, en fin, nos proporciona el suelo seguro de la experiencia interna evidente, resistente a toda crítica procedente de la ciencia empírica o del cinismo posmoderno. La exposición del discurso ético pasa necesariamente por meandros psicológicos y antropológicos, como no podía ser de otra manera. De modo que la doctrina moral de Husserl desvela asimismo e inseparablemente un sustancioso contenido psicológico y antropológico. Por otra parte, se ha preferido mantener en general el estilo fenomenológico del autor, esto es, procediendo analíticamente en sucesivos niveles de profundidad. (shrink)

Este libro es parte de la colección e-Libro en BiblioBoard.

Through skepticism and dialectics, German idealism transformed our understanding of the world and ourselves. This book shows how Kant, Fichte, Schelling, and Hegel revolutionized reason and made possible the critical reversal of values present in 20th-century philosophy.

This article reports a study carried out in order to measure how semantic factors affect reductions in the difficulty of the Chinese Ring Puzzle (CRP) that involves removing five objects according to a recursive rule. We hypothesised that semantics would guide inferences about action decision making. The study involved a comparison of problem solving for two semantic isomorphic variants of the CRP ( fish and fleas ) with problem solving for the puzzle's classic variant (the Balls and Boxes problem; Kotovsky (...) learning involves generalising the relations within a coherent, interconnected whole that makes up the puzzle's rules. It seems that semantics make it easier for the puzzle's elements to be grouped together within coherent, meaningful wholes, which reduces relational complexity and facilitates problem solving. (shrink)

Boghossian’s (2003) proposal to conditionalize concepts as a way to secure their legitimacy in disputable cases applies well, not just to pejoratives – on whose account Boghossian first proposed it – but also to thick ethical concepts. It actually has important advantages when dealing with some worries raised by the application of thick ethical terms, and the truth and facticity of corresponding statements. In this paper, I will try to show, however, that thick ethical concepts present a specific case, whose (...) analysis requires a somewhat different reconstruction from that which Boghossian offers. A proper account of thick ethical concepts should be able to explain how ‘evaluated’ and ‘evaluation’ are connected. (shrink)

Popular Traditions, Folklore and Politics The article studies how the "language" of folk traditions and folklore continues to be a tried-and-tested means for the representation and propagation of political concepts and ideas. The author notes transformations in the significance of folklore and folk traditions in historically changing both political and socio-cultural contexts. Attention is drawn to the significance of folklore in the nation-forming thinking of the 19th century, the place of honour accorded to it as an expression of the working (...) people during the period of socialism, and its contradictory perception in the post-socialist context today. (shrink)